CMSDG Seminar of November 2019 (To register)
Speaker: Gabriel Rocklin, Phd (Pharmacology, Northwestern Univ.)
Title: The structural basis for protein energy landscapes in a de novo designed proteome
Location: Northwestern Univ (Ryan Hall, Room 4003)
Time: 11/12/2019 7pm-8pm (Dinner served at 630pm)
Gabriel is currently a Faculty Member, Center for Synthetic Biology. He received his PhD from UCSF in 2013 and postdoctoral training from U of Washington in 2019. He is working on development of high-throughput methods for protein biophysics and protein design, with a focus on protein therapeutics. Key questions include: How do protein sequence and structure determine folding stability, conformational dynamics, and resistance to aggregation/degradation-inducing stresses? Can we quantitatively predict these protein “phenotypes” from genotype (sequence) using computational modeling? How do we design protein therapeutics that optimize these phenotypes for a particular application? To answer these questions, his group combine large-scale de novo computational protein design with high-throughput methods such as display selections, mass spectrometry proteomics, and next-generation sequencing, enabling to test thousands of proteins in parallel. By combining these technologies, he and his colleagues seek to develop efficient “design-test-analyze” cycles, iterating the way to an improved, quantitative understanding of protein biophysics and more advanced protein therapeutics.