Please join us on Tuesday, April 10th, 2018 at Northwestern University. Dinner starts at 6:30 PM with the seminar immediately following at 7:00 PM. Please be sure to register so our sponsors know how much food to order! We hope you can join us! To register click here
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Title: Maintaining health and diagnosing diseases through protein glycosylation
Speaker: Professor Carlito M. Lebrilla from Department of Chemistry and Department of Biochemistry and Molecular Medicine, University of California, Davis
Abstract: Cells are covered with glycans that maintain viability and play an important role in recognition. When the diseases occur, the glycans are similarly altered. These short carbohydrate chains have previously been difficult to analyze. New analytical methods that provide rapid profiles involving hundreds of compounds with structural identification is increasing our understanding of their roles and are providing new insight into nutrition and maintaining health. Under specific conditions, they are also sources of biomarkers for diseases. This presentation will discuss the role of glycans and oligosaccharides in cell membranes, and how they are used to attract specific microbes for interaction. This strategy is particularly important in human milk where oligosaccharides are used to develop the infant microbiota. In cancer cells and clinical studies, alteration in glycosylation are providing targets for therapeutics as well as for early diagnosis.
Biography: Dr. Carlito B. Lebrilla is a Distinguished Professor at the University of California, Davis in the Department of Chemistry and Biochemistry and Molecular Medicine in the School of Medicine. His research is focused on the development of bioanalytical tools including mass spectrometry to discover disease biomarkers for early diagnosis of cancer and autoimmune diseases using blood biopsies. His group also has a major effort in discovering and developing bioactive foods. The research has resulted in nearly 400 publications in specialized journals and general-topics science journals including Science, Nature, and Cell. His work has been funded by federal grants, industrial partners, and non-governmental organizations. It has also been translated into over a dozen patents. He is a founder of several start-up companies, most notably Evolve Biosystems, which is the first company to sell probiotics specifically for breast fed infants. He received several notable awards including the UC Davis Distinguished Researcher Award. He received his BS degree from the University of California, Irvine and Ph.D. from the University of California, Berkeley. He was an Alexander von Humboldt Fellow and a NSF-NATO Postdoctoral Fellow at the Technical University in Berlin. He returned to the UC as a President’s Fellow and has been at UC Davis since he was an assistant professor. He has served as Chair of the Chemistry Department where he teaches General Chemistry, Advanced Analytical Chemistry, and Special Topics in Mass Spectrometry. He is also co-editor of Mass Spectrometry Reviews and has been on the editorial board of Molecular and Cellular Proteomics, Mass Spectrometry Reviews, Journal of American Society for Mass Spectrometry, European Mass Spectrometry, and International Journal of Mass Spectrometry